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Small RNA-seq comparing transcriptome (small RNAs) of lymphoblastic cells from FAME patients and control individuals

ABSTRACT: RNAseq was performed for 10 individuals: three affected individuals (CSDN14, CSDN15, CSDN16) and one healthy spouse (CSDN17) from Family 1, three affected individuals (CSDN11, CSDN12, CSDN13) from Family 5 and three healthy controls (CSDN18, CSDN19, CSDN20).

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Plassard Damien

PROVIDER: E-MTAB-8300 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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RNA-seq comparing transcriptome of lymphoblastic cells from FAME patients and control individuals

Project description:RNAseq was performed for 10 individuals: three affected individuals (CSDN4, CSDN5, CSDN6) and one healthy spouse (CSDN7) from Family 1, three affected individuals (CSDN1, CSDN2, CSDN3) from Family 5 and three healthy controls (CSDN8, CSDN9, CSDN10).

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Defective mitochondrial translation due to loss of COX14 function triggers ROS-induced inflammation in liver

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Deep sequencing of small RNAs from Mouse brain during aging

Project description:MicroRNAs (miRNAs) are endogenous small RNA molecules that regulate gene expression post-transcriptionally. Work in Caenorhabditis elegans has shown that specific miRNAs function in lifespan regulation and in a variety of age-associated pathways, but the roles of miRNAs in the aging of vertebrates are not well understood. We examined the expression of small RNAs in whole brains of young and old mice by deep sequencing and report here on the expression of 233 known miRNAs and identification of 41 novel miRNAs. Of these miRNAs, 75 known and 18 novel miRNAs exhibit greater than 2.0-fold expression changes. The majority of expressed miRNAs in our study decline in relative abundance in the aged brain, in agreement with trends observed in other miRNA studies in aging tissues and organisms. Target prediction analysis suggests that many of our novel aging-associated miRNAs target genes in the insulin signaling pathway, a central node of aging-associated genetic networks. These novel miRNAs may thereby regulate aging-related functions in the brain. Since mouse miRNAs are conserved in humans, the aging-affected brain miRNAs we report here may represent novel regulatory genes that function during aging in the human brain. 2 samples examined: Mouse brain from two young (5 months) and two old animals (24-25 months).

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Genome-wide copy number variation in Chinese schizophrenia trios

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Mutant Huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure

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Single-cell transcriptomics reveals heterogeneous metabolic profiles in primary human hepatocytes

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Gene expression profiling of AOS Patient fibroblasts against Control fibroblasts

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