Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

The retroelement Lx9 puts a brake on the immune response to virus infection


ABSTRACT: The mammalian genome has an abundance of transposable elements, but understanding their contribution to complex biological systems is poorly understood. Here, we report the CRISPR/Cas9 deletion of a retrotransposon (Lx9c11) in mice and its effect on the immune response to virus infection. The regulatory role for Lx9c11 was assessed by RNA-seq analysis of knockout and wild-type mice, treated with CVB4 virus. Long read nanopore RNA-seq of transcripts enriched from Slfn1 locus (mm10, chr11:83109157-83116657).

INSTRUMENT(S): PromethION, Illumina HiSeq 2000

ORGANISM(S): Mus musculus

SUBMITTER: Nenad Bartonicek 

PROVIDER: E-MTAB-8436 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2015-08-03 | E-GEOD-69168 | biostudies-arrayexpress
2018-10-27 | PXD004634 | Pride
2023-10-24 | PXD035534 | Pride
2014-10-26 | E-GEOD-56473 | biostudies-arrayexpress
2015-06-16 | E-GEOD-67990 | biostudies-arrayexpress
2014-12-31 | E-GEOD-58805 | biostudies-arrayexpress
2013-10-17 | E-GEOD-48785 | biostudies-arrayexpress
2015-12-10 | E-GEOD-73942 | biostudies-arrayexpress
2014-05-26 | E-GEOD-52539 | biostudies-arrayexpress
2014-03-17 | E-GEOD-54794 | biostudies-arrayexpress