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Whole lung gene expression from BXD mouse strains

ABSTRACT: Parental and BXD mouse lines were received from Jackson Laboratory and University of Tennessee Health Science Center. All animals were housed at UTHSC before sacrifice. Mice were killed by cervical dislocation and whole lungs including blood were removed and placed in RNAlater. Total RNA was extracted from the lungs. RNA from two to five animals per strain were pooled and used for gene expression analysis. Animals used in this study were between 49 and 93 days of age. All inbred strains were profiled for both sexes, and for a given BXD strain either males or females were used. Gene expression was measured by microarrays. Several genes which showed a restricted expression to lung tissue were identified. Known QTL regions for respiratory infection susceptibility were investigated and several cis-eQTL genes were identified. Numerous cis- and trans-regulated transcripts and chromosomal intervals with strong regulatory activity were mapped.

ORGANISM(S): Mus musculus

SUBMITTER: Claudia Pommerenke 

PROVIDER: E-MTAB-848 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures.

Alberts Rudi R   Lu Lu L   Williams Robert W RW   Schughart Klaus K  

Respiratory research 20110502

<h4>Background</h4>The lung is critical in surveillance and initial defense against pathogens. In humans, as in mice, individual genetic differences strongly modulate pulmonary responses to infectious agents, severity of lung disease, and potential allergic reactions. In a first step towards understanding genetic predisposition and pulmonary molecular networks that underlie individual differences in disease vulnerability, we performed a global analysis of normative lung gene expression levels in  ...[more]

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