Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): megakaryoblastic leukaemia
SUBMITTER: Augusto Rendon
PROVIDER: E-MTAB-858 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nürnberg Sylvia T ST Rendon Augusto A Smethurst Peter A PA Paul Dirk S DS Voss Katrin K Thon Jonathan N JN Lloyd-Jones Heather H Sambrook Jennifer G JG Tijssen Marloes R MR Italiano Joseph E JE Deloukas Panos P Gottgens Berthold B Soranzo Nicole N Ouwehand Willem H WH
Blood 20120912 24
We recently identified 68 genomic loci where common sequence variants are associated with platelet count and volume. Platelets are formed in the bone marrow by megakaryocytes, which are derived from hematopoietic stem cells by a process mainly controlled by transcription factors. The homeobox transcription factor MEIS1 is uniquely transcribed in megakaryocytes and not in the other lineage-committed blood cells. By ChIP-seq, we show that 5 of the 68 loci pinpoint a MEIS1 binding event within a gr ...[more]