Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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FAIRE-seq of the human megakaryocytic cell line CHRF-288-11


ABSTRACT: FAIRE-seq of the human megakaryocytic cell line CHRF-288-11

ORGANISM(S): Homo sapiens

DISEASE(S): megakaryoblastic leukaemia

SUBMITTER: Augusto Rendon 

PROVIDER: E-MTAB-858 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


We recently identified 68 genomic loci where common sequence variants are associated with platelet count and volume. Platelets are formed in the bone marrow by megakaryocytes, which are derived from hematopoietic stem cells by a process mainly controlled by transcription factors. The homeobox transcription factor MEIS1 is uniquely transcribed in megakaryocytes and not in the other lineage-committed blood cells. By ChIP-seq, we show that 5 of the 68 loci pinpoint a MEIS1 binding event within a gr  ...[more]

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