Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Single-cell RNA-seq of intestinal crypts of Red2Kras and Red2Pi3k mice


ABSTRACT: We isolated mutant and wild-type epithelial cells as well as mesenchymal and immune cells from Confetti, R2Kras and R2Pi3k lines at 2 weeks post-induction and generated single-cell RNA-seq data from them.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Mus musculus

SUBMITTER: Benjamin Simons 

PROVIDER: E-MTAB-8656 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications


Interactions between tumour cells and the surrounding microenvironment contribute to tumour progression, metastasis and recurrence<sup>1-3</sup>. Although mosaic analyses in Drosophila have advanced our understanding of such interactions<sup>4,5</sup>, it has been difficult to engineer parallel approaches in vertebrates. Here we present an oncogene-associated, multicolour reporter mouse model-the Red2Onco system-that allows differential tracing of mutant and wild-type cells in the same tissue. B  ...[more]

Similar Datasets

2023-06-01 | E-MTAB-12391 | biostudies-arrayexpress
2023-12-31 | E-MTAB-11982 | biostudies-arrayexpress
2023-11-09 | E-MTAB-12414 | biostudies-arrayexpress
2023-08-02 | E-MTAB-10498 | biostudies-arrayexpress
2022-02-12 | E-MTAB-10638 | biostudies-arrayexpress
2015-02-21 | E-MTAB-2400 | biostudies-arrayexpress
2014-04-15 | E-MTAB-2428 | biostudies-arrayexpress
2013-09-01 | E-GEOD-40891 | biostudies-arrayexpress
2016-12-05 | PXD004369 | Pride
2023-08-02 | E-MTAB-10499 | biostudies-arrayexpress