Proteomics

Dataset Information

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DSS-induced colitis proteomics after A. caninum ES treatment


ABSTRACT: Analysis of the effect of A. caninum ES proteins on a DSS-induced mouse model of colitis

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Intestine, Lamina Propria, Intestinal Epithelial Cell, Colon

DISEASE(S): Colitis

SUBMITTER: Javier Sotillo  

LAB HEAD: Alex Loukas

PROVIDER: PXD004369 | Pride | 2016-12-05

REPOSITORIES: Pride

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Publications

Changes in protein expression after treatment with Ancylostoma caninum excretory/secretory products in a mouse model of colitis.

Sotillo Javier J   Ferreira Ivana I   Potriquet Jeremy J   Laha Thewarach T   Navarro Severine S   Loukas Alex A   Mulvenna Jason J  

Scientific reports 20170213


Different reports have highlighted the potential use of helminths and their secretions in the treatment of inflammatory bowel disease (IBD) conditions; however, no reports have investigated their effects at a proteome level. Herein, we characterise the protein expression changes that occur in lamina propria (LP) and the intestinal epithelial cells (IEC) of mice with dextran sulfate sodium (DSS)-induced colitis treated with Ancylostoma caninum excretory/secretory (ES) products using a quantitativ  ...[more]

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