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Hypoxia-induced transcriptome and chromatin accessibility alterations in mouse cardiac cell line HL-1

ABSTRACT: In this study, we performed temporal profiling of transcriptome and chromatin accessibility in HL-1 cells for understanding the molecular mechanisms underlying cardiac responses to hypoxia. We collected HL-1 cells under four conditions (4 h and 8 h of hypoxia exposure, 24 h reoxygenation and the normal condition), applied RNA-seq and ATAC-seq to them and performed pairwise comparison of gene expression and open chromatin status on a genome-wide scale.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Mus musculus

SUBMITTER: Weina Hu

PROVIDER: E-MTAB-8814 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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