Transcription profiling of HSV-1 infected murine embryonic stem cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
DISEASE(S): UV inactivated HSV-1 infected
SUBMITTER: Rachael Wash
PROVIDER: E-MTAB-882 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Permissive and restricted virus infection of murine embryonic stem cells.
Wash Rachael R Calabressi Sabrina S Franz Stephanie S Griffiths Samantha J SJ Goulding David D Tan E-Pien EP Wise Helen H Digard Paul P Haas Jürgen J Efstathiou Stacey S Kellam Paul P
The Journal of general virology 20120718 Pt 10
Recent RNA interference (RNAi) studies have identified many host proteins that modulate virus infection, but small interfering RNA 'off-target' effects and the use of transformed cell lines limit their conclusiveness. As murine embryonic stem (mES) cells can be genetically modified and resources exist where many and eventually all known mouse genes are insertionally inactivated, it was reasoned that mES cells would provide a useful alternative to RNAi screens. Beyond allowing investigation of ho ...[more]
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