Measuring ageing-dependent transcriptional responses to human Aβ42 peptide in Drosophila brain
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ABSTRACT: We have shown previously that older flies are intrinsically more susceptible to Aβ42 toxicity. Building upon these findings, this study aimed to determine the mechanisms by which ageing increases this vulnerability to damage in the brain. A fixed dose of Aβ42 peptide was induced in young (5d) versus older (20d) fly neurons, and then gene and protein expression changes examined in dissected fly brains using microarray analyses. This unbiased approach has revealed genes and pathways that correlate with increased susceptibility of the ageing brain to proteotoxicity.
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Fiona Kerr
PROVIDER: E-MTAB-8865 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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