Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptional changes induced by fulvestrant and anastrozole treatment in ER-positive breast cancers


ABSTRACT: Analysis of breast cancer tumors following fulvestrant treatment for 4 weeks. Fulvestrant is a highly specific ER antagonist used to treat postmenopausal women with breast cancer. Data provide insight into the molecular mechanism of action of fulvestrant on whole genome expression.

ORGANISM(S): Homo sapiens

SUBMITTER: Zara Ghazoui 

PROVIDER: E-MTAB-887 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Differences in the transcriptional response to fulvestrant and estrogen deprivation in ER-positive breast cancer.

Patani Neill N   Dunbier Anita K AK   Anderson Helen H   Ghazoui Zara Z   Ribas Ricardo R   Anderson Elizabeth E   Gao Qiong Q   A'hern Roger R   Mackay Alan A   Lindemann Justin J   Wellings Robert R   Walker Jill J   Kuter Irene I   Martin Lesley-Ann LA   Dowsett Mitch M  

Clinical cancer research : an official journal of the American Association for Cancer Research 20140610 15


<h4>Purpose</h4>Endocrine therapies include aromatase inhibitors and the selective estrogen receptor (ER) downregulator fulvestrant. This study aimed to determine whether the reported efficacy of fulvestrant over anastrozole, and high- over low-dose fulvestrant, reflect distinct transcriptional responses.<h4>Experimental design</h4>Global gene expression profiles from ERα-positive breast carcinomas before and during presurgical treatment with fulvestrant (n = 22) or anastrozole (n = 81), and cor  ...[more]

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