Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Zara Ghazoui
PROVIDER: E-MTAB-887 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Patani Neill N Dunbier Anita K AK Anderson Helen H Ghazoui Zara Z Ribas Ricardo R Anderson Elizabeth E Gao Qiong Q A'hern Roger R Mackay Alan A Lindemann Justin J Wellings Robert R Walker Jill J Kuter Irene I Martin Lesley-Ann LA Dowsett Mitch M
Clinical cancer research : an official journal of the American Association for Cancer Research 20140610 15
<h4>Purpose</h4>Endocrine therapies include aromatase inhibitors and the selective estrogen receptor (ER) downregulator fulvestrant. This study aimed to determine whether the reported efficacy of fulvestrant over anastrozole, and high- over low-dose fulvestrant, reflect distinct transcriptional responses.<h4>Experimental design</h4>Global gene expression profiles from ERα-positive breast carcinomas before and during presurgical treatment with fulvestrant (n = 22) or anastrozole (n = 81), and cor ...[more]