Nickel-induced contact dermatitis induce changes in human skin transcriptome over 96 hours
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ABSTRACT: We aimed to characterize transcriptomic changes over time (baseline, 2 hours, 48 hours and 96 hours) after nickel-induced contact dermatitis in 6 human probands. As a contrast, 7 patients with SLS-induced irritant contact dermatitis were included. Therefore, the patch tests were applied onto the back of the individuals and punch biopsies were taken at the respective time points. Only skin with clear reactions was further used for transcriptomic analysis. Using gene set enrichment analysis and leukocyte deconvolution algorithm, we were able to identify important immune cell subsets and related functions within the human skin.
ORGANISM(S): Homo sapiens
SUBMITTER: Lukas Wisgrill
PROVIDER: E-MTAB-8945 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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