Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of undifferentiated human liver-derived intrahepatic cholangiocyte organoids (ICOs)


ABSTRACT: 3D cell culture systems (organoids), cultured from liver biopsies, resemble biliary epthelium (cholangiocytes) upon culture. These intrahepatic cholangiocyte organoids (ICOs) maintain their gentic stability, transcription profile and can be maintained propagated during long periods of culturing while still maintaining their functional properties. The data presented in this ArrayExpress submission contained micro array results of 6 from 15 different ICO lines that were analyzed for their functional cholangiocyte ion-channels, involved in secreting a protective bicarbonate layer. It was shown that these data closely resemble the expression profiles of extrahepatic cholangiocyte organoids (ECOs), previously described by Sampaziotis et al. and deposited in the EMBL-EBI ArrayExpress repository (E-MTAB-4591)

ORGANISM(S): Homo sapiens

SUBMITTER: Henk Roest 

PROVIDER: E-MTAB-9044 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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