RNA-seq of DCIS-pInducer21-SOX11 cells grown in 2D and 3D
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ABSTRACT: Using the pINDUCER21 system, we modified DCIS.com cells so that SOX11 is expressed at much higher levels after induction with Doxycycline (Dox) than observed with the constitutive DCIS-SOX11 cells we have used to model DCIS progression. After Dox induction of pIND21-SOX11 cells, both SOX11 and CD24 expression are significantly increased ). Higher ALDH levels are detected in pIND21-SOX11 cells, suggesting that high levels of SOX11 promotes acquisition of features associated with distinct types of cancer stem cells.
INSTRUMENT(S): Illumina HiSeq 4000
ORGANISM(S): Homo sapiens
SUBMITTER: Erik Oliemuller
PROVIDER: E-MTAB-9108 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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