RNA-Seq of bone marrow derived macophages (BMDMs) and brain tissue isolated from wild type and Irgm1 knockout mice
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 4000
ORGANISM(S): Mus musculus
SUBMITTER: Dr. Santosh Chauhan
PROVIDER: E-MTAB-9164 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response.
Jena Kautilya Kumar KK Mehto Subhash S Nath Parej P Chauhan Nishant Ranjan NR Sahu Rinku R Dhar Kollori K Das Saroj Kumar SK Kolapalli Srinivasa Prasad SP Murmu Krushna C KC Jain Ashish A Krishna Sivaram S Sahoo Bhabani Sankar BS Chattopadhyay Soma S Rusten Tor Erik TE Prasad Punit P Chauhan Swati S Chauhan Santosh S
EMBO reports 20200727 9
Activation of the type 1 interferon response is extensively connected to the pathogenesis of autoimmune diseases. Loss of function of Immunity Related GTPase M (IRGM) has also been associated to several autoimmune diseases, but its mechanism of action is unknown. Here, we found that IRGM is a master negative regulator of the interferon response. Several nucleic acid-sensing pathways leading to interferon-stimulated gene expression are highly activated in IRGM knockout mice and human cells. Mecha ...[more]
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