Dataset Information
Function of ZC3H11 in Trypanosoma brucei
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 1000
ORGANISM(S): Trypanosoma brucei brucei
SUBMITTER: Christine Clayton
PROVIDER: E-MTAB-9311 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Post-transcriptional regulation of the trypanosome heat shock response by a zinc finger protein.
PLoS pathogens 20130404 4
In most organisms, the heat-shock response involves increased heat-shock gene transcription. In Kinetoplastid protists, however, virtually all control of gene expression is post-transcriptional. Correspondingly, Trypanosoma brucei heat-shock protein 70 (HSP70) synthesis after heat shock depends on regulation of HSP70 mRNA turnover. We here show that the T. brucei CCCH zinc finger protein ZC3H11 is a post-transcriptional regulator of trypanosome chaperone mRNAs. ZC3H11 is essential in bloodstream ...[more]
