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Curing Preeclampsia induced by STOX1A expression in Mouse Placentas by Dietary Tetrahydrobiopterin Treatment

ABSTRACT: STOX1A overexpression in mice placenta triggers a preeclamptic phenotype in the mothers, with hypertension, proteinuria and kidney alterations (Doridot et al, Hypertension, 2013), this being connected with NO depletion and increase of nutrosative stress (Doridot et al, Antiox Redox Signal, 2014). Tetrahydrobiopterin (BH4) is a cofactor essential for NO production. We treated preeclamptic mice with this drug, and analyzed placental gene expression in four groups (Control mice, Control mice with BH4, Preeclamptic mice and preeclamptic mice with BH4).

ORGANISM(S): Mus musculus

SUBMITTER: Daniel Vaiman

PROVIDER: E-MTAB-9314 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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