Transcriptome Profiling of Human Monocyte-Derived Macrophages Upon CCL2 Neutralization Reveals an Association Between Activation of Innate Immune Pathways and Restriction of HIV-1
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ABSTRACT: We used RNA-sequencing to deeply characterize the cellular factors and pathways modulated by CCL2 blocking in MDMs and involved in HIV-1 replication restriction. Gene differential expression analysis was performed and then Functional annotation was done to up-regulated genes Reads that failed mapping to human genome was mapped to HIV-1 reference genome. Note that some samples in this experiment have no raw files as the data has been lost.
INSTRUMENT(S): Illumina HiSeq 2500
ORGANISM(S): Homo sapiens
SUBMITTER: Jing Lu
PROVIDER: E-MTAB-9414 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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