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Exiqon miRCURY microRNA array of rat kidney in a model of ischemic preconditioning/ischemia-reperfusion injury

ABSTRACT: Ischemic preconditioning is effective in limiting subsequent ischemic acute kidney injury in experimental models. microRNAs are an important class of post-transcriptional regulator and show promise as biomarkers of kidney injury. An evaluation was performed of the time- and dose-dependent effects of ischemic preconditioning in a rat model of functional (bilateral) ischemia-reperfusion injury. A short, repetitive sequence of ischemic preconditioning resulted in optimal protection from subsequent ischemia-reperfusion injury. A detailed characterization of microRNA expression in ischemic preconditioning/ischemia-reperfusion injury was performed by Exiqon miRCURY microRNA array.

INSTRUMENT(S): Tecan HS4800 hybridization station (Tecan), Agilent G2565BA Microarray Scanner System (Agilent Technologies)

ORGANISM(S): Rattus norvegicus

SUBMITTER: Robert Jenkins

PROVIDER: E-MTAB-9900 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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