Transcription profiling of Wistar rat preconditioned hearts either perfused alone or subjected to ischemia and then reperfused
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ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Michael Zaugg
PROVIDER: E-GEOD-1616 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Ischemic but not pharmacological preconditioning elicits a gene expression profile similar to unprotected myocardium.
da Silva Rafaela R Lucchinetti Eliana E Pasch Thomas T Schaub Marcus C MC Zaugg Michael M
Physiological genomics 20041019 1
Pharmacological (PPC) and ischemic preconditioning (IschPC) provide comparable protection against ischemia in the heart. However, the genomic phenotype may depend on the type of preconditioning. Isolated perfused rat hearts were used to evaluate transcriptional responses to PPC and IschPC in the presence (mediator/effector response) or absence (trigger response) of 40 min of test ischemia using oligonucleotide microarrays. IschPC was induced by 3 cycles of 5 min of ischemia, and PPC by 15 min of ...[more]
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