Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

RNA-seq of splenic follicular B cells from wild-type and IKZF1 L132P mutant mice

ABSTRACT: Comparing the effect of the L132P variant in ZF1 of IKZF1 on the gene expression in sorted follicular B cells.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Mus musculus

SUBMITTER: Anselm Enders

PROVIDER: E-MTAB-9975 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice.

Boast Brigette B Miosge Lisa A LA Kuehn Hye Sun HS Cho Vicky V Athanasopoulos Vicki V McNamara Hayley A HA Sontani Yovina Y Mei Yan Y Howard Debbie D Sutton Henry J HJ Omari Sofia A SA Yu Zhijia Z Nasreen Mariam M Andrews T Daniel TD Cockburn Ian A IA Goodnow Christopher C CC Rosenzweig Sergio D SD Enders Anselm A

Journal of immunology (Baltimore, Md. : 1950) 20210303 7

IKZF1 (IKAROS) is essential for normal lymphopoiesis in both humans and mice. Previous Ikzf1 mouse models have demonstrated the dual role for IKZF1 in both B and T cell development and have indicated differential requirements of each zinc finger. Furthermore, mutations in IKZF1 are known to cause common variable immunodeficiency in patients characterized by a loss of B cells and reduced Ab production. Through N-ethyl-N-nitrosourea mutagenesis, we have discovered a nov ...[more]

PMID: 33658297

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Dataset Information

RNA-seq of splenic follicular B cells from wild-type and IKZF1 L132P mutant mice

Publications

A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice.

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