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RNA-seq of HIV-1 infected long-term non-progressors(LTNPs) and typical progressors(TPs)

ABSTRACT: HIV-infected long-term non-progressors (LTNPs) are a special group of people who can naturally control HIV and maintain good host immunity. Their mechanism is related to viruses, host genetic characteristics, immune response and other factors, but the relationship between the activation level of innate immunity and long-term non-progression is not clear. Therefore,we hypothesize that LTNPs may have some founction to control the HIV replication in vivo.In this study, we used RNA-seq to investigate the transcription（lncRNA, miRNA and mRNA) profiles of LTNPs and typical progressors (TPs).This study is showing expression spectrum of mRNA and non-coding RNA between HIV-infected long-term non-progressors and typical progressors, and analyze the role of mRNA,IncRNA and miRNA in the HIV infected long-term non-progression based on whole transcriptome level.This study reveals the mechanism of different disease progression between LTNPs and TPs through functional enrichment analysis and differentially expressed genes(DEGs) analysis.

INSTRUMENT(S): Illumina HiSeq 4000, BGISEQ-500

ORGANISM(S): Homo sapiens

SUBMITTER: Chen Jie

PROVIDER: E-MTAB-9997 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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