Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human breast carcinomas negative for estrogen, progesterone and HER2/nue receptors

ABSTRACT: 97 triple negative tumors were selected from the fresh-frozen tissue bank of the Netherlands Cancer Institute and gene expression profiles were generated using 35K oligonucleotide microarrays. Human breast carcinomas were snap frozen in liquid nitrogen within one hour after surgery and stored in the fresh-frozen tissue bank of the Netherlands Cancer Institute. RNA from a pool of more than 100 unselected fresh frozen breast carcinomas were isolated and pooled to form the reference to which each individual breast carcinoma is hybridized.

ORGANISM(S): Homo sapiens

SUBMITTER: bas kreike 

PROVIDER: E-NCMF-2 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas.

Kreike Bas B   van Kouwenhove Marieke M   Horlings Hugo H   Weigelt Britta B   Peterse Hans H   Bartelink Harry H   van de Vijver Marc J MJ  

Breast cancer research : BCR 20070101 5

<h4>Introduction</h4>Breast cancer is a heterogeneous group of tumors, and can be subdivided on the basis of histopathological features, genetic alterations and gene-expression profiles. One well-defined subtype of breast cancer is characterized by a lack of HER2 gene amplification and estrogen and progesterone receptor expression ('triple-negative tumors'). We examined the histopathological and gene-expression profile of triple-negative tumors to define subgroups with specific characteristics,  ...[more]

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