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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of replicative senescence in post-selection HMECs, senescent populations from two post-selection HMEC lines (48R and 184) is compared with abundance in isogenic early passage proliferating cells and also with abundance in early passage quiescent cells

ABSTRACT: Transcriptional abundance in each of senescent populations from two post-selection HMEC lines (48R and 184) is compared with abundance in isogenic early passage proliferating cells and also with abundance in early passage quiescent cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Janos Demeter

PROVIDER: E-SMDB-1952 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci.

Zhang Hong H Pan Kuang-Hung KH Cohen Stanley N SN

Proceedings of the National Academy of Sciences of the United States of America 20030307 6

Replicative senescence is the state of irreversible proliferative arrest that occurs as a concomitant of progressive telomere shortening. By using cDNA microarrays and the gabriel system of computer programs to apply domain-specific and procedural knowledge for data analysis, we investigated global changes in gene transcription occurring during replicative senescence in human fibroblasts and mammary epithelial cells (HMECs). Here we report the identification of transcriptional "fingerprints" uni ...[more]

PMID: 12626749

Similar Datasets

Replicative senescence in post-selection HMECs

Project description:Transcriptional abundance in each of senescent populations from two post-selection HMEC lines (48R and 184) is compared with abundance in isogenic early passage proliferating cells and also with abundance in early passage quiescent cells. A strain or line experiment design type assays differences between multiple strains, cultivars, serovars, isolates, lines from organisms of a single species. Keywords: strain_or_line_design

2005-12-03 | GSE3731 | GEO

Replicative senescence in post-selection HMECs

2005-12-02 | E-GEOD-3731 | biostudies-arrayexpress

Transcription profiling of human fibroblasts, senescent populations from three cell lines (WS1, WI38 and BJ) is compared with abundance in isogenic early passage proliferating cells and also with abundance in early passage quiescent cells

2005-10-07 | E-SMDB-1951 | biostudies-arrayexpress

Replicative senescence in human fibroblasts

Project description:Transcriptional abundance in each of senescent populations from three cell lines (WS1, WI38 and BJ) is compared with abundance in isogenic early passage proliferating cells and also with abundance in early passage quiescent cells. A strain or line experiment design type assays differences between multiple strains, cultivars, serovars, isolates, lines from organisms of a single species. Keywords: strain_or_line_design

2005-12-03 | GSE3730 | GEO

Replicative senescence in human fibroblasts

2005-12-02 | E-GEOD-3730 | biostudies-arrayexpress

Madin Darby Canine Kidney (MDCK) Cells: Early & Late Passage

Project description:The paracellular passage of ions in epithelial systems is dictated by the repertoire of tight junction (TJ) proteins, the number and architecture of apicolateral TJ strands, and the interaction of TJ proteins with the cytoskeleton. To investigate the relative contribution of these factors and to explore their regulation, we examined a passage number dependent phenotypic change in Madin Darby Canine Kidney (MDCK) cells iteratively passaged at low density in which dilution potentials of the monolayer abruptly decreased but transepithelial resistance (TER) progressively increased. Here, we report that the phenotypic transition involved a decrease surface expression of peanut agglutinin (PNA), a decrease in steady state levels of claudin-1 and a slight decrease in E-cadherin expression in the context of an apparently claudin-2-negative system. Late passage cells grew in more densely packed monolayers and exhibited characteristics of a competent, functional cultured monolayer including inducible vectorial ion transport in response to norepinephrine (NE) and sphere formation in three dimensional laminin gel culture. Microarray analysis of gene expression levels in early and late passage cells revealed an increase in transcript abundance for SGK and GLUT-3, and a reduction Id-3. The steady state protein expression levels of GLUT-3, however, were found to be equivalent. These findings suggest that the expression of claudin-2 in MDCK cells could be contingent on signaling via lateral cell contacts and that claudin-1, in the context of sustained claudin-8 expression, could function as a negative regulator of overall TER.

2010-02-13 | GSE14837 | GEO

Early and late passage endothelial cells with or without PDCD10 downregulation

2014-04-10 | GSE54095 | GEO

Madin Darby Canine Kidney (MDCK) Cells: Early & Late Passage

2010-04-09 | E-GEOD-14837 | biostudies-arrayexpress

Early and late passage endothelial cells with or without PDCD10 downregulation

Project description:Primary cells deficient for PDCD10/CCM3 do not enter senescence as control cells. Microarray analysis was performed in cells transduced with non-targeting shRNA and CCM3 shRNA at passage 7 (early passage) and passage 11 (late passage), when control cells are already senescent. Primary endothelial cells were transduced either with non-target shRNA or with CCM3 shRNA. RNA was extracted at passage 7 and passage 11

2014-04-10 | E-GEOD-54095 | biostudies-arrayexpress

Genotype data from early passage UACC melanoma cell lines

Project description:eQTL is a powerful method to detect genotype-expression correlation. To be able to identify the genes whose expression levels are correlated with melanoma-associated common variants, eQTL analysis was performed in 59 early passage melanoma cell lines

2017-07-01 | GSE99193 | GEO

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