Transcription profiling of human skeletal muscle reveals that insulin regulates approximately 800 genes during a hyperinsulinemic clamp
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Janos Demeter
PROVIDER: E-SMDB-2315 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Microarray profiling of human skeletal muscle reveals that insulin regulates approximately 800 genes during a hyperinsulinemic clamp.
Rome Sophie S Clément Karine K Rabasa-Lhoret Rémi R Loizon Emmanuelle E Poitou Christine C Barsh Greg S GS Riou Jean-Paul JP Laville Martine M Vidal Hubert H
The Journal of biological chemistry 20030305 20
Insulin action in target tissues involved precise regulation of gene expression. To define the set of insulin-regulated genes in human skeletal muscle, we analyzed the global changes in mRNA levels during a 3-h hyperinsulinemic euglycemic clamp in vastus lateralis muscle of six healthy subjects. Using 29,308 cDNA element microarrays, we found that the mRNA expression of 762 genes, including 353 expressed sequence tags, was significantly modified during insulin infusion. 478 were up-regulated and ...[more]
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