Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human foreskin fibroblasts CRL 2091 (ATCC) serum starved for 48 hours, Serum Stimulation time series

ABSTRACT: Foreskin fibroblasts CRL 2091 (ATCC) were serum starved for 48 hours, and harvested at the indicated time points after switching to media with 10% FBS essentially as described (Iyer et al., 1999). RNA from all of the sampled time points were pooled as reference RNA to compare with RNA from individual time points as described (Iyer et al., 1999).

ORGANISM(S): Homo sapiens

SUBMITTER: Janos Demeter 

PROVIDER: E-SMDB-2503 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.

Chang Howard Y HY   Sneddon Julie B JB   Alizadeh Ash A AA   Sood Ruchira R   West Rob B RB   Montgomery Kelli K   Chi Jen-Tsan JT   van de Rijn Matt M   Botstein David D   Brown Patrick O PO  

PLoS biology 20040113 2

Cancer invasion and metastasis have been likened to wound healing gone awry. Despite parallels in cellular behavior between cancer progression and wound healing, the molecular relationships between these two processes and their prognostic implications are unclear. In this study, based on gene expression profiles of fibroblasts from ten anatomic sites, we identify a stereotyped gene expression program in response to serum exposure that appears to reflect the multifaceted role of fibroblasts in wo  ...[more]

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