Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human innate immune responses (host response) to bacteria

ABSTRACT: The innate immune response is crucial for defense against microbial pathogens. To investigate the molecular choreography of this response, we carried out a systematic examination of the gene expression program in human peripheral blood mononuclear cells responding to bacteria and bacterial products. We found a remarkably stereotyped program of gene expression induced by bacterial lipopolysaccharide and diverse killed bacteria. An intricately choreographed expression program devoted to communication between cells was a prominent feature of the response. Other features suggested a molecular program for commitment of antigen-presenting cells to antigens captured in the context of bacterial infection. Despite the striking similarities, there were qualitative and quantitative differences in the responses to different bacteria. Modulation of this host-response program by bacterial virulence mechanisms was an important source of variation in the response to different bacteria.

ORGANISM(S): Homo sapiens

SUBMITTER: Janos Demeter

PROVIDER: E-SMDB-573 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Stereotyped and specific gene expression programs in human innate immune responses to bacteria.

Boldrick Jennifer C JC Alizadeh Ash A AA Diehn Maximilian M Dudoit Sandrine S Liu Chih Long CL Belcher Christopher E CE Botstein David D Staudt Louis M LM Brown Patrick O PO Relman David A DA

Proceedings of the National Academy of Sciences of the United States of America 20020101 2

The innate immune response is crucial for defense against microbial pathogens. To investigate the molecular choreography of this response, we carried out a systematic examination of the gene expression program in human peripheral blood mononuclear cells responding to bacteria and bacterial products. We found a remarkably stereotyped program of gene expression induced by bacterial lipopolysaccharide and diverse killed bacteria. An intricately choreographed expression program devoted to communicat ...[more]

PMID: 11805339

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Dataset Information

Transcription profiling of human innate immune responses (host response) to bacteria

Publications

Stereotyped and specific gene expression programs in human innate immune responses to bacteria.

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