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Comparative genomic hybridization of 100 favourable histology Wilms tumour samples taken at immediate nephrectomy in order to identify changes in DNA copy number associated with clinical outcome


ABSTRACT: We have carried out microarray-based comparative genomic hybridisation (arrayCGH) on 100 favourable histology Wilms tumour samples taken at immediate nephrectomy in order to identify changes in DNA copy number associated with clinical outcome. Tumour DNA was co-hybridised with normal female genomic DNA onto microarrays consisting of 4263 BAC clones with an approximate 1Mb spacing throughout the genome. Data was normalised and quality-filtered, an adapted weights smoothing algorithm fitted, and changes in DNA copy number assessed for each clone.

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Anita Grigoriadis 

PROVIDER: E-TABM-10 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Amplification and overexpression of CACNA1E correlates with relapse in favorable histology Wilms' tumors.

Natrajan Rachael R   Little Suzanne E SE   Reis-Filho Jorge S JS   Hing Lara L   Messahel Boo B   Grundy Paul E PE   Dome Jeffrey S JS   Schneider Toni T   Vujanic Gordan M GM   Pritchard-Jones Kathy K   Jones Chris C  

Clinical cancer research : an official journal of the American Association for Cancer Research 20061201 24


<h4>Purpose</h4>The most well established molecular markers of poor outcome in Wilms' tumor are loss of heterozygosity at chromosomes 1p and/or 16q, although to date no specific genes at these loci have been identified. We have previously shown a link between genomic gain of chromosome 1q and tumor relapse and sought to further elucidate the role of genes on 1q in treatment failure.<h4>Experimental design</h4>Microarray-based comparative genomic hybridization identified a microamplification harb  ...[more]

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