Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of human cytogenetically normal acute myeloid leukemia patient samples with FLT3 internal tandem duplications

ABSTRACT: Oligonucleotide expression microarray data used for expression signature associated with FLT3 internal tandem duplications(FLT3-ITD) in samples from older patients with cytogenetically normal AML

ORGANISM(S): Homo sapiens

SUBMITTER: Guido Marcucci 

PROVIDER: E-TABM-1029 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

FLT3 internal tandem duplication associates with adverse outcome and gene- and microRNA-expression signatures in patients 60 years of age or older with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.

Whitman Susan P SP   Maharry Kati K   Radmacher Michael D MD   Becker Heiko H   Mrózek Krzysztof K   Margeson Dean D   Holland Kelsi B KB   Wu Yue-Zhong YZ   Schwind Sebastian S   Metzeler Klaus H KH   Wen Jing J   Baer Maria R MR   Powell Bayard L BL   Carter Thomas H TH   Kolitz Jonathan E JE   Wetzler Meir M   Moore Joseph O JO   Stone Richard M RM   Carroll Andrew J AJ   Larson Richard A RA   Caligiuri Michael A MA   Marcucci Guido G   Bloomfield Clara D CD  

Blood 20100723 18

The clinical impact of FLT3-internal tandem duplications (ITDs), an adverse prognostic marker in adults aged < 60 years with primary cytogenetically normal acute myeloid leukemia (CN-AML), requires further investigation in older patients. In CN-AML patients aged ≥ 60 years treated on Cancer and Leukemia Group B frontline trials, we found that FLT3-ITD remained associated with shorter disease-free survival (P < .001; hazard ratio = 2.10) and overall survival (P < .001; hazard ratio = 1.97) in mul  ...[more]