Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptomic Analysis of Embryonic Mammary Cells


ABSTRACT: The mammary primordium represents the earliest evidence of commitment to the mammary lineage. The primordium forms via inductive tissue interactions between its constitutive tissues, the mesenchyme and epithelium. Here, we describe an analysis of the transcriptome of the mammary bud epithelium and its associated mesenchyme, two distinct cellular compartments that comprise the mammary primordium. Using network analysis, we found candidate mediators of mammary cell fate, differentiation and progenitor cell function that signal from mammary lineage inception during embryogenesis through postnatal development. Genetic features of mammary primordial cells overlapping with human breast progenitor cells identified potential regulators of key progenitor cell functions conserved across species. These results provide new insights into genetic regulatory mechanisms of mammary and in particular novel regulators of stromal-epithelial communications.

ORGANISM(S): Mus musculus

SUBMITTER: Alan Mackay 

PROVIDER: E-TABM-1099 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment.

Wansbury Olivia O   Mackay Alan A   Kogata Naoko N   Mitsopoulos Costas C   Kendrick Howard H   Davidson Kathryn K   Ruhrberg Christiana C   Reis-Filho Jorge S JS   Smalley Matthew J MJ   Zvelebil Marketa M   Howard Beatrice A BA  

Breast cancer research : BCR 20110811 4


<h4>Introduction</h4>The mammary primordium forms during embryogenesis as a result of inductive interactions between its constitutive tissues, the mesenchyme and epithelium, and represents the earliest evidence of commitment to the mammary lineage. Previous studies of embryonic mouse mammary epithelium indicated that, by mid-gestation, these cells are determined to a mammary cell fate and that a stem cell population has been delimited. Mammary mesenchyme can induce mammary development from simpl  ...[more]

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