Transcriptome analysis of Neisseria meningitidis strain MC58 in GC medium
Ontology highlight
ABSTRACT:
ORGANISM(S): Neisseria meningitidis
SUBMITTER: Alessandro Muzzi
PROVIDER: E-TABM-1113 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Transcriptome analysis of Neisseria meningitidis in human whole blood and mutagenesis studies identify virulence factors involved in blood survival.
Echenique-Rivera Hebert H Muzzi Alessandro A Del Tordello Elena E Seib Kate L KL Francois Patrice P Rappuoli Rino R Pizza Mariagrazia M Serruto Davide D
PLoS pathogens 20110505 5
During infection Neisseria meningitidis (Nm) encounters multiple environments within the host, which makes rapid adaptation a crucial factor for meningococcal survival. Despite the importance of invasion into the bloodstream in the meningococcal disease process, little is known about how Nm adapts to permit survival and growth in blood. To address this, we performed a time-course transcriptome analysis using an ex vivo model of human whole blood infection. We observed that Nm alters the expressi ...[more]
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