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Transcriptome analysis of wt and PerR mutant Group A streptococcus (GAS), strain 003Sm in THB medium, with and without hydrogen peroxide

ABSTRACT: Transcriptome analysis of of wt and PerR mutant Group A streptococcus strain 003Sm grown in the presence or absence of hydrogen peroxide, at early and late log

ORGANISM(S): Streptococcus pyogenes

SUBMITTER: Renata Grifantini/Annalisa Colaprico

PROVIDER: E-MTAB-646 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Peroxide stimulon and role of PerR in group A Streptococcus.

Grifantini Renata R Toukoki Chadia C Colaprico Annalisa A Gryllos Ioannis I

Journal of bacteriology 20110923 23

We have characterized group A Streptococcus (GAS) genome-wide responses to hydrogen peroxide and assessed the role of the peroxide response regulator (PerR) in GAS under oxidative stress. Comparison of transcriptome changes elicited by peroxide in wild-type bacteria with those in a perR deletion mutant showed that 76 out of 237 peroxide-regulated genes are PerR dependent. Unlike the PerR-mediated upregulation of peroxidases and other peroxide stress defense mechanisms previously reported in gram ...[more]

PMID: 21949080

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