Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Expression Array_Glioma_stem_cells

ABSTRACT: We evaluated the gene expression profiles of the 1228- and 0316-Glioma-initiating cells (GICs), as well as the original glioblastoma tissues from which they were derived, plus neural stem cells and normal brain tissues. Short- and long-term cultures of 0316-GICs (2 and 6 months, respectively) were also included in the analysis in order to evaluate the potential effects of in vitro culture duration on gene expression. Expressional changes by EZH2 depletion and DZnep treatment were also evaluated.

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Atsushi Natsume

PROVIDER: E-TABM-1121 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma.

Natsume Atsushi A Ito Motokazu M Katsushima Keisuke K Ohka Fumiharu F Hatanaka Akira A Shinjo Keiko K Sato Shinya S Takahashi Satoru S Ishikawa Yuta Y Takeuchi Ichiro I Shimogawa Hiroki H Uesugi Motonari M Okano Hideyuki H Kim Seung U SU Wakabayashi Toshihiko T Issa Jean-Pierre J JP Sekido Yoshitaka Y Kondo Yutaka Y

Cancer research 20130529 14

Tumor cell plasticity contributes to functional and morphologic heterogeneity. To uncover the underlying mechanisms of this plasticity, we examined glioma stem-like cells (GSC) where we found that the biologic interconversion between GSCs and differentiated non-GSCs is functionally plastic and accompanied by gain or loss of polycomb repressive complex 2 (PRC2), a complex that modifies chromatin structure. PRC2 mediates lysine 27 trimethylation on histone H3 and in GSC it affected pluripotency or ...[more]

PMID: 23720055

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Dataset Information

Expression Array_Glioma_stem_cells

Publications

Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma.

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