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Transcription profiling of biopsies from the descending colon of Crohns disease patients

ABSTRACT: Biopsies from the descending colon were obtained colonoscopically from 46 Crohn's disease patients (33 from areas without inflammation and 18 from inflamed areas). Gene profiling analyses were performed using Human Genome U133 Plus 2.0 GeneChip Array. Hybridization data were analyzed with dChip software.

ORGANISM(S): Homo sapiens

SUBMITTER: Claudio Csillag

PROVIDER: E-TABM-118 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Clinical phenotype and gene expression profile in Crohn's disease.

Csillag Claudio C Nielsen Ole Haagen OH Borup Rehannah R Nielsen Finn Cilius FC Olsen Jørgen J

American journal of physiology. Gastrointestinal and liver physiology 20060907 1

The clinical course varies significantly among patients with Crohn's disease (CD). This study investigated whether gene expression profiles generated by DNA microarray technology might predict disease progression. Biopsies from the descending colon were obtained colonoscopically from 40 CD patients. Gene profiling analyses were performed using a Human Genome U133 Plus 2.0 GeneChip Array, and summarization into a single expression measure for each probe set was performed using the robust multiple ...[more]

PMID: 16959948

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