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Transcription profiling of human Mo7e cells transduced with control- or p210(BCR-ABL)-GFP viruses

ABSTRACT: The profiles of transcripts of Mo7e cells transduced with control- or p210(BCR-ABL)-GFP viruses were compared using microarrays to investigate

ORGANISM(S): Homo sapiens

SUBMITTER: Hugues Ripoche

PROVIDER: E-TABM-173 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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p210(BCR-ABL) reprograms transformed and normal human megakaryocytic progenitor cells into erythroid cells and suppresses FLI-1 transcription.

Buet D D Raslova H H Geay J-F JF Jarrier P P Lazar V V Turhan A A Morlé F F Vainchenker W W Louache F F

Leukemia 20070222 5

The BCR-ABL oncoprotein exhibits deregulated protein tyrosine kinase activity and is implicated in the pathogenesis of Philadelphia chromosome (Ph)-positive human leukemias. Here, we report that ectopic expression of p210(BCR-ABL) in the megakaryoblastic Mo7e cell line and in primary human CD34(+) progenitors trigger erythroid differentiation at the expense of megakaryocyte (MK) differentiation. Clonal culture of purified CD41(+)CD42(-) cells, a population highly enriched in MK progenitors, comb ...[more]

PMID: 17315025

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