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Transcription profiling of yeast expressing wild type C. albicans G33 ser-tRNACAG and the mutant T33 ser-tRNACAG which trigger genetic code ambiguity

ABSTRACT: S. cerevisiae expressing the wild-type C. albicans G33 ser-tRNACAG and the mutant T33 ser-tRNACAG that trigger genetic code ambiguity were compared against control yeast using two-color oligo arrays

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Joel Arrais

PROVIDER: E-TABM-196 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Critical roles for a genetic code alteration in the evolution of the genus Candida.

Silva Raquel M RM Paredes João A JA Moura Gabriela R GR Manadas Bruno B Lima-Costa Tatiana T Rocha Rita R Miranda Isabel I Gomes Ana C AC Koerkamp Marian J G MJ Perrot Michel M Holstege Frank C P FC Boucherie Hélian H Santos Manuel A S MA

The EMBO journal 20071011 21

During the last 30 years, several alterations to the standard genetic code have been discovered in various bacterial and eukaryotic species. Sense and nonsense codons have been reassigned or reprogrammed to expand the genetic code to selenocysteine and pyrrolysine. These discoveries highlight unexpected flexibility in the genetic code, but do not elucidate how the organisms survived the proteome chaos generated by codon identity redefinition. In order to shed new light on this question, we have ...[more]

PMID: 17932489

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