Transcription profiling of human primary skin fibroblasts throughout the cell cycle after synchronization by serum starvation or by serum starvation and thymidine blocking
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Itamar Simon
PROVIDER: E-TABM-263 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genome-wide transcriptional analysis of the human cell cycle identifies genes differentially regulated in normal and cancer cells.
Bar-Joseph Ziv Z Siegfried Zahava Z Brandeis Michael M Brors Benedikt B Lu Yong Y Eils Roland R Dynlacht Brian D BD Simon Itamar I
Proceedings of the National Academy of Sciences of the United States of America 20080114 3
Characterization of the transcriptional regulatory network of the normal cell cycle is essential for understanding the perturbations that lead to cancer. However, the complete set of cycling genes in primary cells has not yet been identified. Here, we report the results of genome-wide expression profiling experiments on synchronized primary human foreskin fibroblasts across the cell cycle. Using a combined experimental and computational approach to deconvolve measured expression values into "sin ...[more]
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