Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Aurelien de Reynies
PROVIDER: E-TABM-311 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Caramuta Stefano S Lee Linkiat L Ozata Deniz M DM Akçakaya Pinar P Xie Hong H Höög Anders A Zedenius Jan J Bäckdahl Martin M Larsson Catharina C Lui Weng-Onn WO
Endocrine-related cancer 20130704 4
Deregulation of microRNA (miRNA) expression in adrenocortical carcinomas (ACCs) has been documented to have diagnostic, prognostic, as well as functional implications. Here, we evaluated the mRNA expression of DROSHA, DGCR8, DICER (DICER1), TARBP2, and PRKRA, the core components in the miRNA biogenesis pathway, in a cohort of 73 adrenocortical tumors (including 43 adenomas and 30 carcinomas) and nine normal adrenal cortices using a RT-qPCR approach. Our results show a significant over-expression ...[more]