Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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MESO-JD


ABSTRACT: A Cartes dM-^RIdentite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net/) | Affymetrix HG-U133 Plus 2.0 : 43 samples. Characteristics[OS.event] means the survival status (0: dead/1:alive). Characteristics[OS_delay] means the survival delay form diagnosis to the last follow up. Characteristics[Asbestos.Exposure] : exposure history to the asbestos (E: Exposed, PE: probably exposed, NE: not exposed). BAP1.Gene.mutation: (M: mutated, WT: wild type). Characteristics[CDKN2B.Gene.mutation]: (M: mutated, WT: wild type) . Characteristics[CTNNB1.Gene.mutation]: (M: mutated, WT: wild type). Characteristics[NF2.Gene.mutation]: (M: mutated, WT: wild type). Characteristics[P14ARF.Gene.mutation]: (M: mutated, WT: wild type). Characteristics[P16INKa.Gene.mutation]: (M: mutated, WT: wild type). Characteristics[TP53.Gene.mutation]: (M: mutated, WT: wild type). Characteristics[molecular.subgroup]: the clusters identified by the unsupervised analyses of gene expression. NOTE: This experiment was updated on 10th April 2014. The following changes were made: 5 samples (MPM39, MPM40, MPM41, MPM42, MPM430) and their associated data files were removed. Histology values were updated and the column headings regarding gene mutations were modified.

ORGANISM(S): Homo sapiens

SUBMITTER: Nabila Elarouci 

PROVIDER: E-MTAB-1719 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Molecular classification of malignant pleural mesothelioma: identification of a poor prognosis subgroup linked to the epithelial-to-mesenchymal transition.

de Reyniès Aurélien A   Jaurand Marie-Claude MC   Renier Annie A   Couchy Gabrielle G   Hysi Ilir I   Elarouci Nabila N   Galateau-Sallé Françoise F   Copin Marie-Christine MC   Hofman Paul P   Cazes Aurélie A   Andujar Pascal P   Imbeaud Sandrine S   Petel Fabien F   Pairon Jean-Claude JC   Le Pimpec-Barthes Francoise F   Zucman-Rossi Jessica J   Jean Didier D  

Clinical cancer research : an official journal of the American Association for Cancer Research 20140117 5


<h4>Purpose</h4>Despite research efforts to develop more effective diagnostic and therapeutic approaches, malignant pleural mesothelioma (MPM) prognosis remains poor. The assessment of tumor response to therapy can be improved by a deeper phenotypical classification of the tumor, with emphasis on its clinico-biological heterogeneity. The identification of molecular profiles is a powerful approach to better define MPM subclasses and targeted therapies.<h4>Experimental design</h4>Molecular subclas  ...[more]

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