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MicroRNA profiling of human ovarian carcinomas to identify profiles to discrimate between cancerous and non-cancerous ovarian tissues and different groups of tumors

ABSTRACT: MicroRNA miRNA expression profiles for human ovarian carcinomas were examined to investigate the miRNA involvement in the development of this neoplasia. miRNA microarray analysis identified statistical unique profiles, which could discriminate ovarian carcinomas from noncancerous ovarian tissues, and different groups of tumors classified according to histo-pathological characteristics.

INSTRUMENT(S): Scanning hardware

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Cristian Taccioli 

PROVIDER: E-TABM-343 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Epithelial ovarian cancer (EOC) is the sixth most common cancer in women worldwide and, despite advances in detection and therapies, it still represents the most lethal gynecologic malignancy in the industrialized countries. Unfortunately, still relatively little is known about the molecular events that lead to the development of this highly aggressive disease. The relatively recent discovery of microRNAs (miRNA), a class of small noncoding RNAs targeting multiple mRNAs and triggering translatio  ...[more]

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