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MicroRNA profiling by array of human metastatic breast cancer

ABSTRACT: metastatic breast cancer miRNA

ORGANISM(S): Homo sapiens

DISEASE(S): Breast Normal

SUBMITTER: Stefano Volinia 

PROVIDER: E-TABM-971 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Reprogramming of miRNA networks in cancer and leukemia.

Volinia Stefano S   Galasso Marco M   Costinean Stefan S   Tagliavini Luca L   Gamberoni Giacomo G   Drusco Alessandra A   Marchesini Jlenia J   Mascellani Nicoletta N   Sana Maria Elena ME   Abu Jarour Ramzey R   Desponts Caroline C   Teitell Michael M   Baffa Raffaele R   Aqeilan Rami R   Iorio Marilena V MV   Taccioli Cristian C   Garzon Ramiro R   Di Leva Gianpiero G   Fabbri Muller M   Catozzi Marco M   Previati Maurizio M   Ambs Stefan S   Palumbo Tiziana T   Garofalo Michela M   Veronese Angelo A   Bottoni Arianna A   Gasparini Pierluigi P   Harris Curtis C CC   Visone Rosa R   Pekarsky Yuri Y   de la Chapelle Albert A   Bloomston Mark M   Dillhoff Mary M   Rassenti Laura Z LZ   Kipps Thomas J TJ   Huebner Kay K   Pichiorri Flavia F   Lenze Dido D   Cairo Stefano S   Buendia Marie-Annick MA   Pineau Pascal P   Dejean Anne A   Zanesi Nicola N   Rossi Simona S   Calin George A GA   Liu Chang-Gong CG   Palatini Jeff J   Negrini Massimo M   Vecchione Andrea A   Rosenberg Anne A   Croce Carlo M CM  

Genome research 20100501 5

We studied miRNA profiles in 4419 human samples (3312 neoplastic, 1107 nonmalignant), corresponding to 50 normal tissues and 51 cancer types. The complexity of our database enabled us to perform a detailed analysis of microRNA (miRNA) activities. We inferred genetic networks from miRNA expression in normal tissues and cancer. We also built, for the first time, specialized miRNA networks for solid tumors and leukemias. Nonmalignant tissues and cancer networks displayed a change in hubs, the most  ...[more]

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