Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Josette-Renee Landry
PROVIDER: E-TABM-431 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Landry Josette-Renée JR Bonadies Nicolas N Kinston Sarah S Knezevic Kathy K Wilson Nicola K NK Oram S Helen SH Janes Mary M Piltz Sandie S Hammett Michelle M Carter Jacinta J Hamilton Tina T Donaldson Ian J IJ Lacaud Georges G Frampton Jonathan J Follows George G Kouskoff Valerie V Göttgens Berthold B
Blood 20090126 23
The Lmo2 gene encodes a transcriptional cofactor critical for the development of hematopoietic stem cells. Ectopic LMO2 expression causes leukemia in T-cell acute lymphoblastic leukemia (T-ALL) patients and severe combined immunodeficiency patients undergoing retroviral gene therapy. Tightly controlled Lmo2 expression is therefore essential, yet no comprehensive analysis of Lmo2 regulation has been published so far. By comparative genomics, we identified 17 highly conserved noncoding elements, 9 ...[more]