Transcription profiling of wild type, Pfsir2A knock-out and Pfsir2B knock-out Plasmodium falciparum intra-erythrocytic stages
Ontology highlight
ABSTRACT:
ORGANISM(S): Plasmodium falciparum
SUBMITTER: Celine Carret
PROVIDER: E-TABM-438 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum.
Tonkin Christopher J CJ Carret Céline K CK Duraisingh Manoj T MT Voss Till S TS Ralph Stuart A SA Hommel Mirja M Duffy Michael F MF Silva Liliana Mancio da LM Scherf Artur A Ivens Alasdair A Speed Terence P TP Beeson James G JG Cowman Alan F AF
PLoS biology 20090401 4
Cytoadherance of Plasmodium falciparum-infected erythrocytes in the brain, organs and peripheral microvasculature is linked to morbidity and mortality associated with severe malaria. Parasite-derived P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1) molecules displayed on the erythrocyte surface are responsible for cytoadherance and undergo antigenic variation in the course of an infection. Antigenic variation of PfEMP1 is achieved by in situ switching and mutually exclusive transcription of ...[more]
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