Methylation profiling of human placenta, sperm, liver and CD8+ T cells using a genomic tiling array
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ABSTRACT: We have generated and validated a genomic tiling array that can be used to analyse genetic and epigenetic features of the MHC. We demonstrated its utility for DNA methylation profiling and the identification of tDMRs. Based on our experience, we expect the array to be suitable for a number of assays (e.g. aCGH, ChIP-chip and expression analysis) relevant to medical genomics and are currently in the process of applying it to investigate the down-regulation of HLA class I molecules, a phenotype commonly associated with cancer
ORGANISM(S): Homo sapiens
SUBMITTER: Stephan Beck
PROVIDER: E-TABM-471 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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