Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of the temporal hepatic response to high-fat diets in ApoE3 Leiden mice


ABSTRACT: A time-course study of the effects of two types of high-fat diets on liver transcriptome in the context of metabolic syndrome development using ApoE3Leiden mice

ORGANISM(S): Mus musculus

SUBMITTER: Marijana Radonjic 

PROVIDER: E-TABM-553 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program.

Radonjic Marijana M   de Haan Jorn R JR   van Erk Marjan J MJ   van Dijk Ko Willems KW   van den Berg Sjoerd A A SA   van den Berg Sjoerd A A SA   de Groot Philip J PJ   Müller Michael M   van Ommen Ben B  

PloS one 20090814 8


<h4>Background</h4>Excessive exposure to dietary fats is an important factor in the initiation of obesity and metabolic syndrome associated pathologies. The cellular processes associated with the onset and progression of diet-induced metabolic syndrome are insufficiently understood.<h4>Principal findings</h4>To identify the mechanisms underlying the pathological changes associated with short and long-term exposure to excess dietary fat, hepatic gene expression of ApoE3Leiden mice fed chow and tw  ...[more]

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