Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Cristian Taccioli
PROVIDER: E-TABM-763 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Visone Rosa R Rassenti Laura Z LZ Veronese Angelo A Taccioli Cristian C Costinean Stefan S Aguda Baltazar D BD Volinia Stefano S Ferracin Manuela M Palatini Jeff J Balatti Veronica V Alder Hansjuerg H Negrini Massimo M Kipps Thomas J TJ Croce Carlo M CM
Blood 20090828 18
Chromosomal abnormalities, immunoglobulin heavy chain variable-region (IGHV) gene mutation status, and zeta-associated protein 70 (ZAP-70) expression levels have independent prognostic relevance in chronic lymphocytic leukemia (CLL); however, their concordance is variable. Because deregulation of microRNAs has been linked to disease initiation and progression in CLL, we studied the value of the microRNAs as a signature for CLL patients with specific chromosomal abnormalities. We identified 32 mi ...[more]