Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of mouse wild type and DNA repair-deficient Rad54/Rad54B embryonic fibroblasts after treatment with a clastogen

ABSTRACT: Transcriptional responses in mouse embryonic fibroblasts to clastogens, mutagens, and control

ORGANISM(S): Mus musculus

SUBMITTER: Anuska Mahabir

PROVIDER: E-TABM-786 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Comparison of clastogen-induced gene expression profiles in wild-type and DNA repair-deficient Rad54/Rad54B cells.

Mahabir Anuska G AG Schaap Mirjam M MM Pennings Jeroen L A JL van Benthem Jan J Hendriksen Coenraad F M CF van Steeg Harry H

BMC genomics 20100112

<h4>Background</h4>Previously we found that Rad54/Rad54B cells are more sensitive towards mitomycin C (MMC) as compared to wild-type (WT) cells. This difference in sensitivity was absent upon exposure to other clastogens like bleomycin (BLM) and gamma-radiation. In order to get further insight into possible underlying mechanisms, gene expression changes in WT and Rad54/Rad54B MEFs (mouse embryonic fibroblasts) after exposure to the clastogens MMC and BLM were investigated. Exposures of these cel ...[more]

PMID: 20067618

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Dataset Information

Transcription profiling of mouse wild type and DNA repair-deficient Rad54/Rad54B embryonic fibroblasts after treatment with a clastogen

Publications

Comparison of clastogen-induced gene expression profiles in wild-type and DNA repair-deficient Rad54/Rad54B cells.

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