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Transcription profiling of human Chronic Lymphocytic Leukemia samples

ABSTRACT: Microarray technology was used to predict the outcome of Chronic Lymphocytic Leukemia

INSTRUMENT(S): microarray scanner system

ORGANISM(S): Homo sapiens

DISEASE(S): chronic lymphocytic leukemia

SUBMITTER: Raquel Villuendas

PROVIDER: E-TABM-80 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Molecular heterogeneity in chronic lymphocytic leukemia is dependent on BCR signaling: clinical correlation.

Rodríguez A A Villuendas R R Yáñez L L Gómez M E ME Díaz R R Pollán M M Hernández N N de la Cueva P P Marín M C MC Swat A A Ruiz E E Cuadrado M A MA Conde E E Lombardía L L Cifuentes F F Gonzalez M M García-Marco J A JA Piris M A MA

Leukemia 20070705 9

Chronic lymphocytic leukemia (CLL), the most frequent form of adult leukemia in Western countries, is characterized by a highly variable clinical course. Expression profiling of a series of 160 CLL patients allowed interrogating the genes presumably playing a role in pathogenesis, relating the expression of functionally relevant signatures with the time to treatment. First, we identified genes relevant to the biology and prognosis of CLL to build a CLL disease-specific oligonucleotide microarray ...[more]

PMID: 17611561

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