Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Cristian Taccioli
PROVIDER: E-TABM-868 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Tili Esmerina E Michaille Jean-Jacques JJ Liu Chang-Gong CG Alder Hansjuerg H Taccioli Cristian C Volinia Stefano S Calin George A GA Croce Carlo M CM
Nucleic acids research 20100717 21
MicroRNAs (miRNAs) are small regulatory RNAs targeting multiple effectors of cell homeostasis and development, whose malfunctions are associated with major pathologies such as cancer. Herein we show that GAM/ZFp/ZNF512B works within an intricate gene regulatory network involving cell-cycle regulators, TGFβ effectors and oncogenic miRNAs of the miR-17-92 cluster. Thus, GAM impairs the transcriptional activation of the miR-17-92 promoter by c-Myc, downregulates miR-17-92 miRNAs differentially, and ...[more]