Transcription profiling of human invasive and non-invasive non-functioning pituitary adenomas

ABSTRACT: Context : Non Functioning Pituitary Adenomas (NFPAs), although typically benign, may be locally invasive. Few datas are currently available related to the molecular process of invasion in sporadic pituitary adenomas. Markers of invasiveness, important for helping the clinician in the therapeutic strategy particularly in the decision for adjuvant radiotherapy, are currently lacking. Objective: Evaluate if invasive NFPAs display a specific expression profile compared with non invasive tumors. Methods: To address this issue, we selected 40 NFPAs (38 of the gonadotroph type) and classified them as invasive (n=22) or non invasive (n=18) on the basis of MRI and surgical findings. Then we performed pangenomic analysis based on Agilent Human Whole genome Gene Expression oligonucleotide microa

ORGANISM(S): Homo sapiens

DISEASE(S): invasive pituitary adenoma

SUBMITTER: Philippe DESSEN 

PROVIDER: E-TABM-899 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress