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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Kinase activity profiling of human locally advanced rectal cancer samples

ABSTRACT: Locally advanced rectal cancer characterized by multiplex kinase activity profiling

ORGANISM(S): Homo sapiens

SUBMITTER: Anne Hansen Ree

PROVIDER: E-TABM-913 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Prediction of response to preoperative chemoradiotherapy in rectal cancer by multiplex kinase activity profiling.

Folkvord Sigurd S Flatmark Kjersti K Dueland Svein S de Wijn Rik R Grøholt Krystyna Kotanska KK Hole Knut H KH Nesland Jahn M JM Ruijtenbeek Rob R Boender Piet J PJ Johansen Marianne M Giercksky Karl-Erik KE Ree Anne Hansen AH

International journal of radiation oncology, biology, physics 20100802 2

<h4>Purpose</h4>Tumor response of rectal cancer to preoperative chemoradiotherapy (CRT) varies considerably. In experimental tumor models and clinical radiotherapy, activity of particular subsets of kinase signaling pathways seems to predict radiation response. This study aimed to determine whether tumor kinase activity profiles might predict tumor response to preoperative CRT in locally advanced rectal cancer (LARC).<h4>Methods and materials</h4>Sixty-seven LARC patients were treated with a CRT ...[more]

PMID: 20675069

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